Genetic identity combining mutation and drift

Impact of selection, mutation rate and genetic drift on human genetic variation.

The accumulation of genome-wide information on single nucleotide polymorphisms in humans provides an unprecedented opportunity to detect the evolutionary forces responsible for heterogeneity of the level of genetic variability across loci. Previous studies have shown that history of recombination events has produced long haplotype blocks in the human genome, which contribute to this heterogenei...

Mutation-Drift Balance

Genetic drift

What is genetic drift? Say you have a population of 5,000 people. That makes 10,000 copies of each gene. Imagine a gene where 3,000 of those copies are of one particular allele or type. In the next generation, there won’t necessarily be exactly 3,000 copies again. There may be 3,050 or 2,960 copies instead. Some gametes get randomly picked out of all the possible gametes that could have been us...

Drift-barrier hypothesis and mutation-rate evolution.

Mutation dictates the tempo and mode of evolution, and like all traits, the mutation rate is subject to evolutionary modification. Here, we report refined estimates of the mutation rate for a prokaryote with an exceptionally small genome and for a unicellular eukaryote with a large genome. Combined with prior results, these estimates provide the basis for a potentially unifying explanation for ...

Genetic drift and polygenic inheritance.

The interaction of random gene drift and selection was studied by computer simulation for two quantitative traits, which were considered to approximate stature and skin color dlfferences in human populations. The expected effects of gene drift, fixation of alleles and reduction of genotypic and phenotypic variances, were found in the simulation. Stabilizing selection, which seems to be the type...